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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NAE1
All Species:
32.42
Human Site:
S446
Identified Species:
54.87
UniProt:
Q13564
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13564
NP_001018169.1
534
60246
S446
Q
G
R
Y
P
G
V
S
N
Y
Q
V
E
E
D
Chimpanzee
Pan troglodytes
XP_001159531
534
60179
S446
H
G
R
Y
P
G
V
S
N
Y
Q
V
E
E
D
Rhesus Macaque
Macaca mulatta
XP_001085059
534
60247
S446
H
G
R
Y
P
G
V
S
N
Y
Q
V
E
E
D
Dog
Lupus familis
XP_852003
534
60357
S446
H
G
R
Y
P
G
V
S
N
Y
Q
V
E
E
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8VBW6
534
60255
S446
H
G
R
Y
P
G
V
S
N
Y
Q
V
E
E
D
Rat
Rattus norvegicus
Q9Z1A5
534
60364
S446
H
G
R
Y
P
G
V
S
N
Y
Q
V
E
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505632
525
59197
H437
H
G
R
F
P
G
V
H
N
Y
Q
V
E
E
D
Chicken
Gallus gallus
Q5ZIE6
535
60465
Y447
H
G
R
Y
P
G
V
Y
N
Y
Q
V
E
D
D
Frog
Xenopus laevis
Q6NTW6
533
60607
Y445
L
G
R
Y
P
G
I
Y
N
Y
Q
I
E
S
D
Zebra Danio
Brachydanio rerio
Q7SXP2
533
60386
Y445
H
S
R
Y
P
G
V
Y
N
Y
Q
V
E
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VTE9
524
58698
G436
S
E
C
G
N
I
P
G
E
C
I
V
E
Q
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18217
541
60764
A453
G
V
P
V
S
I
D
A
Q
D
L
K
K
R
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42744
540
60016
D452
N
K
F
P
G
Q
F
D
G
G
M
D
E
D
I
Baker's Yeast
Sacchar. cerevisiae
Q12059
462
52834
L378
L
P
P
K
S
D
L
L
G
I
F
S
T
S
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99.4
97.7
N.A.
97
96.8
N.A.
82.7
83.9
78.8
73
N.A.
45.1
N.A.
37.7
N.A.
Protein Similarity:
100
99.6
99.4
98.8
N.A.
98.6
98.3
N.A.
91.1
93
89.6
85.9
N.A.
64.2
N.A.
55.4
N.A.
P-Site Identity:
100
93.3
93.3
93.3
N.A.
93.3
93.3
N.A.
80
80
66.6
80
N.A.
20
N.A.
0
N.A.
P-Site Similarity:
100
93.3
93.3
93.3
N.A.
93.3
93.3
N.A.
86.6
86.6
80
80
N.A.
26.6
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.8
25.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.7
46.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
8
8
0
8
0
8
0
15
79
% D
% Glu:
0
8
0
0
0
0
0
0
8
0
0
0
86
58
0
% E
% Phe:
0
0
8
8
0
0
8
0
0
0
8
0
0
0
0
% F
% Gly:
8
65
0
8
8
72
0
8
15
8
0
0
0
0
0
% G
% His:
58
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
15
8
0
0
8
8
8
0
0
8
% I
% Lys:
0
8
0
8
0
0
0
0
0
0
0
8
8
0
0
% K
% Leu:
15
0
0
0
0
0
8
8
0
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
8
0
0
0
8
0
0
0
72
0
0
0
0
0
8
% N
% Pro:
0
8
15
8
72
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
8
0
0
8
0
72
0
0
8
0
% Q
% Arg:
0
0
72
0
0
0
0
0
0
0
0
0
0
8
0
% R
% Ser:
8
8
0
0
15
0
0
43
0
0
0
8
0
15
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% T
% Val:
0
8
0
8
0
0
65
0
0
0
0
72
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
65
0
0
0
22
0
72
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _